Aims and Scope
High Impact, Rapid publication, Open access, Broad exposure
In aging research, evidence emerges that aging is controlled by genetic mechanisms
involving signal transduction pathways highly conserved from yeast to mammals.
Hyper-stimulation of certain signaling pathways drives the aging process and is
involved in cell senescence and age-related disease. Modulation of DNA-damage
response, sirtuins and stress-response, insulin-activated pathways, nutrient-sensing
pathways, p53, FOXO and PTEN extends life span. And calorie restriction extends life
span by modulating the same signaling pathways. This provides a potential means of
pharmacologic intervention to extend life span and treat age-related diseases. This
new journal welcomes scientists in all disciplines, not only those in traditional
high-impact research papers of general interest and biological significance
in all fields of aging research including but not limited to cellular
senescence, DNA damage and repair, organismal aging, age-related diseases, genetic control
of aging from yeast to mammals, regulation of longevity, evolution of
aging, anti-aging strategies and drug development and especially the
role of signal transduction pathways in aging and potential approaches
to modulate these signaling pathways to extend lifespan.
AGING covers (in addition to traditional topics on aging) many other
topics including cellular and molecular biology (regulation of translation,
cell growth, death and autophagy, mitochondria, DNA damage and repair,
microRNAs, stem cells), human age-related diseases, pathology in model
organisms, cancer and first of all signal transduction pathways (p53, sirtuins,
PI-3K/AKT/mTOR and so on) and approaches to modulate these signaling pathways.
The Editorial Board
Includes outstanding scientists in gerontology, genetics, signal transduction,
stem cells and stem cell aging, cell growth, cell cycle, apoptosis, cancer
research, pharmacology and clinical medicine.
About Our Authors
We have published outstanding papers and reviews by Lawrence Donehower, Toren Finkel, Stephen Helfand,
Elizabeth Blackburn, Gerald Shadel, Andre Nussenzweig, Maurice Burg, Karen Vousden, Leonard Guarente and other highly
cited authors, who usually publish their papers in Cell, Nature, Science and PNAS.
AGING is now indexed by PubMed/Medline and PubMed Central.