Research Paper Volume 15, Issue 13 pp 6380—6399
DSC2 suppresses the growth of gastric cancer through the inhibition of nuclear translocation of γ-catenin and PTEN/PI3K/AKT signaling pathway
Figure 6. Downregulation of DSC2 expression promoted the γ-catenin nuclear translocation of MGC-803 cells. After being transfected with siDSC2 in MGC-803 cells, (A) the expression level of γ-catenin, BCL-2 and P53 in nucleus was determined by Western blot assay. (B) The distribution of γ-catenin in cells was detected by immunofluorescence assay. The scale bar = 20 μm. (C) The expressions of γ-catenin and P53 were detected by Western blot assay. The data are represented as mean ± SEM, n=3. ***p<0.001 vs. BC. ###p<0.001 vs. Si-NC.