Research Paper Volume 15, Issue 14 pp 7023—7037

Figure 4. Cell-cell communication network in tumor microenvironment. (A, B) Circle plots showing the number (left) and strength (right) of cell interactions in tumor microenvironment. The edge width is proportional to the numbers or strength of significant ligand-receptor pairs. (C) Comparisons of the numbers of intercellular interactions with contribution degree more than 0.25 among all cell clusters. (D) Dot plots depict the incoming patterns of target cells, which shows the correspondence between the inferred latent patterns and cell clusters, as well as signaling pathways. (E) Outgoing communication patterns of secreting cells.