Research Paper Volume 15, Issue 19 pp 10031—10056
Huangqi Guizhi Wuwu decoction promotes M2 microglia polarization and synaptic plasticity via Sirt1/NF-κB/NLRP3 pathway in MCAO rats
Figure 8. EX527 notably weakened the modulation of HGWD on PSD95, Sirt1 and NLRP3 expression. (A) PSD95 expression in each group. Left, representative western blot. Right, Quantitative analysis of PSD95. (B) Sirt1 expression in each group. Left, representative western blot. Right, Quantitative analysis of Sirt1. (C) NLRP3 expression in each group. Left, representative western blot. Right, Quantitative analysis of NLRP3. (D) Schematic representation of mechanisms by which HGWD protect against MCAO injury. ##P < 0.01 vs. control group; **P< 0.01 vs. model group. ##P < 0.01 vs. control group; **P< 0.01 vs. model group.