Research Paper Volume 15, Issue 17 pp 9041—9058
Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage
Figure 3. Gal-3 aggravated the inflammatory response after ICH. (A, B) Double immunofluorescence analysis of microglia(yellow) and M1-microglia (green) in brain and the percentage of M1-positive microglia was analysed, arrow indicated M1-microglia positive cells. (C) TNF-α in CSF. (D) IL-1β in CSF. (E) IL-6 in CSF. (F) TNF-α in serum. (G) IL-1β in serum. (H) IL-6 in serum. Nuclei were labeled with DAPI (blue). Scale bar =50 μm. The black dots represent individual data in each group. **p < 0.01 and *p < 0.05 vs. Sham group, @@p < 0.01 and @p < 0.05 vs. ICH+shRNA-con group, &&p < 0.01 and &p < 0.05 vs. ICH+Lv-con group, n = 6.