Research Paper Volume 15, Issue 19 pp 10168—10192

Identification and validation of obesity related genes signature based on microenvironment phenotypes in prostate adenocarcinoma

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Figure 4. ORGs risk score associated with immune microenvironment is a valuable prognostic model in TCGA cohort. (A) In the multivariate COX regression, age, Pathologic_T, Pathologic_N, Gleason_score and ORGs risk score were used to construct a forest map. (B) The ROC curve of indicating that the risk score was better than other models for predicting the 3-year survival condition of PRAD patients. (C) The ROC curve of indicating that the risk score was better than other models for predicting the 5-year survival condition of PRAD patients. (D) A nomogram was constructed using independent prognostic factors such as age, Pathologic_T, Pathologic_N, Gleason_score and ORGs risk score. (E) The calibration diagrams were applied to evaluate 3- and 5-years overall survival probabilities. (F) The Net Benefit plot showed that the ORGs model had better net benefit than other models in the quantity of false positives.