Research Paper Volume 15, Issue 20 pp 11588—11610
Immunobiological signatures and the emerging role of SPP1 in predicting tumor heterogeneity, malignancy, and clinical outcomes in stomach adenocarcinoma
Figure 12. Down-regulation of SPP1 inhibits proliferation and migration abilities of HGC27 and NCI-N87 cells. (A) Compared with the negative control group in HGC27 and NCI-N87 cells, SPP1 in siRNA transfection group was down-regulated in protein and mRNA expression levels. (B) Compared with the control group, the down-regulation of SPP1 significantly inhibited the proliferation of STAD cells. (C, D) Downregulation of SPP1 expression can significantly inhibit the metastatic ability of gastric cancer cells. ***p < 0.001; **p < 0.01.