Research Paper Volume 15, Issue 21 pp 11970—11984
Identification of epithelial-mesenchymal transition-related biomarkers in lung adenocarcinoma using bioinformatics and lab experiments
Figure 1. Construction of the EMT-associated gene signature. (A) 1916 genes were significantly correlated with EMT (P < 0.001, R > 0.2). (B) 1250 DEGs were obtained between tumorous tissues and the matched normal tissues, including 445 upregulated DEGs and 805 downregulated DEGs (|logFC| > 2, FDR < 0.001). (C) There were 90 overlapping genes between 1916 EMT-associated genes and 445 upregulated DEGs. (D, E) 52 genes were screened using LASSO regression analysis, and eight genes (CCNB1, PLEK2, DERL3, C1QTNF6, DLGAP5, HMMR, GJB3, and SPOCK1) were eventually obtained for construction of the EMT-associated gene signature.