Research Paper Volume 15, Issue 21 pp 12618—12632
High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression
Figure 6. Graphical abstract: schematic illustration of proposed mechanisms underlying the HMGB1-induced inhibition of muscle regeneration, where HMGB1 inhibits Pax-7 expression and skeletal muscle regeneration by promoting the synthesis of miR-342-5p via RAGE, TLR2, TLR4, and c-Src signaling pathways.