Atorvastatin mitigates memory deficits and brain monocyte infiltration in chronic hypercholesterolemia

Fengchao Gong; Qian Shi; Xiaojie Mou; Kang Wang; Qianqian Wang; Haitao Wang

doi:doi:10.18632/aging.205217

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Research Paper Volume 15, Issue 23 pp 13669—13679

Atorvastatin mitigates memory deficits and brain monocyte infiltration in chronic hypercholesterolemia

Figure 5. Atorvastatin prevented the enlarged blood-brain barrier (BBB) permeability in aged ApoE^-/- mice. Diffusion of sodium fluorescent in treated animals’ cortex (ng/mg protein) was used to index BBB integrity (**, P<0.01 vs. vehicle; #, P<0.05 vs. ApoE^-/- mice group).