Research Paper Volume 15, Issue 22 pp 13558—13578

Lnc-PTCHD4-AS inhibits gastric cancer through MSH2-MSH6 dimerization and ATM-p53-p21 activation

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Figure 7. PTCHD4-AS inhibited GC growth and increased cisplatin sensitivity in vivo. (A) Schematic diagram of the xenograft tumor model of GC. (B) Images of xenograft tumors in different treatment groups at the end of the experiment. (C) Tumor growth curves of different treatment groups. (D) Tumor weights of different treatment groups at the end of the experiment. (E) Tumor inhibition rate of CDDP between EV and PTCHD4-AS groups. (F) Representative images and proportion of positive cells of Ki67 detected by IHC and apoptotic cells detected by TUNEL. Data are presented as mean ± SD, * P < 0.05, ** P < 0.01, *** P < 0.001.