Research Paper Volume 15, Issue 24 pp 15451—15472
Identification and validation of key biomarkers associated with macrophages in nonalcoholic fatty liver disease based on hdWGCNA and machine learning
Figure 9. Enrichment analyses by ssGSEA and single-gene GSEA. (A) The specific distribution of 50 hallmark gene sets in the NAFLD group and control group samples. (B) The correlation analysis of 50 hallmark gene sets and 2 top feature genes. (C) Gene sets enrichment analysis (GSEA) identifies top five signaling pathways that are significantly enriched in the high expression of MAFB or CX3CR1. (D) Circle plot showing the communication strength between interacting cells. (E) Scatter plot indicating the incoming and outgoing interaction strength of the cells. (F) The dot plot showing the comparison of outgoing and incoming signaling patterns. (G) The cell communication between MAFB+ macrophages and other cells in the GALECTIN signaling pathway. *P < 0.05, **P < 0.01, ***P < 0.001.