Research Paper Volume 16, Issue 3 pp 2249—2272
Identification of gut microbes-related molecular subtypes and their biomarkers in colorectal cancer
Figure 4. Immunological characterization and evaluation of immunotherapy for GM molecular subtypes. (A) Relative content distribution of 22 TICs in COAD samples. (B) Box plots showing the difference in abundance of 22 TICs between the two subtypes. (C) Comparison of stromal, immune, and ESTIMATE scores in the two subtypes. (D) Estimation of immunotherapy effect in the two subtypes using the TIDE algorithm. (E) Immune checkpoint expression in two GM subtypes. (F) Box plots of the estimated IC50 of chemotherapy drugs between the two GM subtypes. Abbreviations: GM: gut microbes; TICs: tumor-infiltrating immune cells; TIDE: Tumor Immune Dysfunction and Exclusion; IC50: semi-inhibitory concentration.